Pulmonary metastatic chordoma treated with platinum-based chemotherapy; A case report

Chordoma is a rare malignant neoplasm arising from remnants of notochordal cells along the spinal axis. It occurs along the spinal axis with most tumors arising in the sacrococcygeal and sphenooccipital regions, with the remaining tumors arising along the cervical, thoracic, and lumbar spine. As the chordoma has been considered primarily a local disease associated with a high incidence of local recurrence and with a poor long-term prognosis, treatment recommendations for chordoma typically involve radical resection and subsequent radiotherapy. Despite the low potential for metastasis, chordoma-induced metastatic lesions have been noted in the liver, lungs, lymph nodes, peritoneum, skin, heart, brain, and distant regions of the spine. However, there is little data on the treatment modalities, especially on chemotherapeutic treatments, for chordoma-induced metastatic diseases to date. Herein, we present a case of the metastatic chordoma to the lung, which regressed by the platinum-based combined chemotherapy.